I don't think there are any "secrets" as far as pickup locations. And if there are, nobody is going to share. There's a lot of luck involved in getting pings when it's so over saturated with drivers, anyways.
I'm gonna go ahead and say the answer to your question is Eastbank though
East bank - French Quarter, Bourbon st, casino, 3 major colleges, Frenchman st,hotels, 4 malls and airport
West bank - swamps
Did you really have to ask the question or you really that new to the city?